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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described as focusing on practical aspects of designing a study which include recruitment and consent, adherence and the use routinely available equipment.

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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and helps to reduce bias in the results. However too much heterogeneity could result in problems with the design of the trial.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually commissioned by policymakers and 프라그마틱 무료체험 practitioners in order to guide their decisions. They can also be used to determine the causality of an intervention with its outcomes. They should not, however, be used to replace explanatory studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a pragmatic study, including recruitment, design and delivery of the intervention, 프라그마틱 정품 as well as follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, as shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.