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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study which include recruitment and consent, adherence and the use routinely available equipment.

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Pragmatic, a software company provides a variety of casino games for online gambling platforms. Its iGaming solutions are used by the most reputable operators as well as land-based casinos. The company provides front-end site design tools, analysis tools and marketing, promotions, security payment systems, customer support and bug-reporting. In addition, the company provides its players a secure environment with high-quality graphics and gameplay.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from various geographical areas. This kind of heterogeneity, which is vital for a pragmatic trial to be valid and to reduce bias in the results, is also necessary. However too much heterogeneity could result in issues with the design of the trial.

Pragmatic Play, a major player on the live casino market, offers an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic experience in gambling as well a full range of virtual betting options. The company has also created numerous interactive game shows that make online gambling fun. Some of these shows are hosted live, while others are hosted by famous personalities from the industry.

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Legality

Pragmatic Play has earned a reputation for providing top-notch games and an exceptional user experience. Its software can be used on mobile devices and in multiple languages. Despite its relatively young age it has already established itself as a premier gaming platform for casinos. Its latest releases include Wolves, a 5-reel video slot that has a healthy RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. They are typically commissioned by practitioners and policy makers to guide their decision-making. They also provide a useful way to identify the causality between an intervention and its results. However, they shouldn't be used in lieu for explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials can replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a practical trial, including the recruitment process, the design and implementation of the intervention, and follow-up.

There is an encouraging increase in the number pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note that the majority of these trials were conducted in primary care settings.